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<div data-page-id="doxcnzfrnYhhLgEevEzQvlTKdqb" data-docx-has-block-data="true"> <div class="ace-line ace-line old-record-id-doxcneqKSCkg0cKIsQRBpq1pFjd"><span class="p">根據(jù)一項新的研究，血液測試可以通過識別血細胞產(chǎn)生的變化來提前幾年預(yù)測老年人群中患白血病的風(fēng)險。</span></div> <div class="ace-line ace-line old-record-id-doxcnGSoGGQsi4ywS6MwjNZ6Efh"><span class="p">&nbsp;</span></div> <div class="image-uploaded gallery old-record-id-doxcnkyYGiyaQYWOoIRnpw6M4ce" style="text-align: justify;" data-type="image" data-ace-gallery-json="{&quot;items&quot;:[{&quot;uuid&quot;:&quot;219c4b49-c369-4783-9c9e-290b83e24c9c&quot;,&quot;height&quot;:480,&quot;width&quot;:720,&quot;currHeight&quot;:480,&quot;currWidth&quot;:720,&quot;natrualHeight&quot;:480,&quot;natrualWidth&quot;:720,&quot;pluginName&quot;:&quot;imageUpload&quot;,&quot;scale&quot;:1,&quot;src&quot;:&quot;https%3A%2F%2Finternal-api-drive-stream.feishu.cn%2Fspace%2Fapi%2Fbox%2Fstream%2Fdownload%2Fall%2FboxcnK0Wxp9iXp2TGGm8CRdXB9b%2F%3Fmount_node_token%3DdoxcnkyYGiyaQYWOoIRnpw6M4ce%26mount_point%3Ddocx_image&quot;,&quot;file_token&quot;:&quot;boxcnK0Wxp9iXp2TGGm8CRdXB9b&quot;,&quot;image_type&quot;:&quot;image/jpeg&quot;,&quot;size&quot;:72553,&quot;comments&quot;:[]}]}"><span class="p"><img src="https://info.compassedu.hk/sucai/content/1658387324038/1658387324038.png" width="808" height="538" /></span></div> <div class="ace-line ace-line old-record-id-doxcnUosqMucuQISAEb7v565F9c"><span class="p">專家說，通過識別風(fēng)險最大的人，應(yīng)該有可能在未來提供預(yù)防性或早期治療，以改善患者的預(yù)后。</span></div> <div class="ace-line ace-line old-record-id-doxcna4gQ6S44GmMayeSwpGGMsf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcncIiyiAKsMy4qqYvPTw7mdd"><span class="p">白血病通常是血細胞生產(chǎn)中精細平衡中斷的結(jié)果，其中制造新細胞而舊血細胞死亡。</span></div> <div class="ace-line ace-line old-record-id-doxcn4CeS6ywGMIOw437Pqwxd4g"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnWG2aw2K0wKUM6wwrNTMs9f"><span class="p">隨著年齡的增長，血液干細胞的突變可能意味著改變的細胞可以比其他血細胞具有生長益處，并且在所謂的健身優(yōu)勢方面超過它們。</span></div> <div class="ace-line ace-line old-record-id-doxcnO4SAgGkmo0w6oPSSPPA8yb"><span class="p">&nbsp;</span></div> <h2 class="heading-2 ace-line old-record-id-doxcnGWs2aiioimC4aSvyYyx3Xb"><span class="p">調(diào)查更改</span></h2> <div class="ace-line ace-line old-record-id-doxcnAYqEEmuSSyMUqOC9vVfOGe"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnqsiAE86C8yC8G5wrWJ8H73"><span class="p">來自愛丁堡大學(xué)和格拉斯哥大學(xué)的研究人員調(diào)查了血液生產(chǎn)中發(fā)生的適應(yīng)性優(yōu)勢的變化如何根據(jù)發(fā)生的突變類型為患白血病的風(fēng)險提供線索。</span></div> <div class="ace-line ace-line old-record-id-doxcnEwUmioKkIgm4stQzpRakBc" style="text-align: justify;"><span class="p">&nbsp;</span></div> <blockquote class=" old-record-id-doxcnuEEeSQCqAOCUwP7jx52D6W" data-type="quote_container"> <div class="ace-line ace-line old-record-id-doxcnq2iKIOmU0aoYeONxOjJrue" style="text-align: justify;"><em><span class="h6">我們測量了洛錫安出生隊列中83名老年人血液樣本的變化，在12年內(nèi)每三年采集一次。利用數(shù)學(xué)家，生物學(xué)家和基因組科學(xué)家的綜合知識，我們開始了解這些變化對我們隨著年齡增長而患白血病的風(fēng)險意味著什么。</span></em></div> <div class="ace-line ace-line old-record-id-doxcnk4Mc2aayQcKcuYiG3tlkVd" style="text-align: justify;"><em><span class="h6">&nbsp;</span></em></div> <div class="ace-line ace-line old-record-id-doxcnU44gOYQkY8CCIDuvotq50f" style="text-align: justify;"><em><span class="h6">塔米爾&middot;錢德拉博士愛丁堡大學(xué)MRC人類遺傳學(xué)系校長研究員</span></em></div> </blockquote> <div class="ace-line ace-line old-record-id-doxcn6EyoUOOIgWIeW2vj3uQ70e"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcniS6COYyqIuSqozZRmWR2dh"><span class="p">Lothian Birth Cohorts 1921和1936是對大腦，認知和一般衰老的縱向研究，每3年對1921年70至82歲的個體和1936年的79至92歲之間的個體進行隨訪。</span></div> <div class="ace-line ace-line old-record-id-doxcniEMs68wCgKUIxz0SkJ617J"><span class="p">&nbsp;</span></div> <h3 class="heading-3 ace-line old-record-id-doxcnIYiQQcoGiC2oUDNGjIJwzh"><span class="p">突變</span></h3> <div class="ace-line ace-line old-record-id-doxcn4qc8wU0SW2QIu1GpOMBxcb"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcni6GsYqoakmgmOYPhB3XWfh"><span class="p">然后，該團隊將這些復(fù)雜的基因組數(shù)據(jù)與機器學(xué)習(xí)算法相結(jié)合，將不同的突變與攜帶這些突變的血液干細胞的不同生長速度聯(lián)系起來。</span></div> <div class="ace-line ace-line old-record-id-doxcnWgYsW6QGU0gUmE6qAftlrf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcncMosqWsCmGI82bxWHcNwnh"><span class="p">研究發(fā)現(xiàn)，特定的突變?yōu)樵跊]有白血病的人中測量的干細胞提供了明顯的適應(yīng)性優(yōu)勢 - 這可以用來預(yù)測突變細胞生長的速度，這決定了白血病的風(fēng)險。</span></div> <div class="ace-line ace-line old-record-id-doxcn420yA8sESWOY0u1KwXB3Xf"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnY6OKymckc4cMgNSrxRls8f"><span class="p">該團隊表示，由于當(dāng)前研究中的樣本量有限，需要進一步的研究來驗證這些結(jié)果在更大的人群中。</span></div> <div class="ace-line ace-line old-record-id-doxcnSiw6IMemA4wgS4SFl87z2b"><span class="p">&nbsp;</span></div> <blockquote class=" old-record-id-doxcnKmSe8cU4QIKoaKuMTQOT1c" data-type="quote_container"> <div class="ace-line ace-line old-record-id-doxcniAGYge2GUKeSU7ATcoQ5Qb" style="text-align: justify;"><span class="h6">在了解個體患者患白血病的風(fēng)險后，臨床醫(yī)生可以安排那些最有可能患上這種疾病的人的預(yù)約間隔更短，并提供早期治療，這更有可能成功。</span></div> <div class="ace-line ace-line old-record-id-doxcnOGgecueEaUiQiyy00F5r5c" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIkg6yuAMSG6s0rwKoYJXhb" style="text-align: justify;"><span class="h6">克里斯蒂娜&middot;基爾希納博士共同主要作者，格拉斯哥大學(xué)癌癥科學(xué)研究所高級講師</span></div> <div class="ace-line ace-line old-record-id-doxcnOSeK8sCqS2sA8gbpBIGxGc" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnsuuaIUGU4OIGYBfMfFquQe" style="text-align: justify;"><span class="h6">為了了解白血病的風(fēng)險，我們需要考慮參與血細胞生產(chǎn)的不同細胞之間的平衡，以及這種平衡如何隨著年齡的增長而變化。通過將基因組數(shù)據(jù)與機器學(xué)習(xí)聯(lián)系起來，我們已經(jīng)能夠根據(jù)血細胞產(chǎn)生的突變來預(yù)測它們的未來行為。</span></div> <div class="ace-line ace-line old-record-id-doxcnImcCuY4ScEiwmeG9BVEg8b" style="text-align: justify;"><span class="h6">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnu08CcuUMk4GCEpUXelEnWg" style="text-align: justify;"><span class="h6">萊納斯&middot;舒馬赫博士愛丁堡大學(xué)再生醫(yī)學(xué)中心的共同主要作者和校長研究員</span></div> </blockquote> <div class="ace-line ace-line old-record-id-doxcnOEIc44O6g6qiiKPuiscZlc"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnIIaeEAwcSsaeq2XjCDgssg"><span class="p">這些發(fā)現(xiàn)已發(fā)表在《自然醫(yī)學(xué)》雜志上。這項研究由醫(yī)學(xué)研究委員會，英國白血病和英國癌癥研究中心資助。</span></div> <div class="ace-line ace-line old-record-id-doxcnoYw28GYmgyYGMz5vAZpUgQ"><span class="p">&nbsp;</span></div> <div class="ace-line ace-line old-record-id-doxcnQMsYoCgsUQAsOsFZwJJW5d"><span class="p">Lothian Birth隊列獲得生物技術(shù)和生物科學(xué)研究委員會，經(jīng)濟和社會研究委員會，Age UK，Wellcome，皇家學(xué)會，醫(yī)學(xué)研究委員會和愛丁堡大學(xué)的資助。</span></div> </div>